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br Materials and methods br Data and statistical analysis
2020-01-21
Materials and methods Data and statistical analysis The results were expressed as mean ± SEM. One-way analysis of variance (ANOVA), followed by Bonferroni\'s post-test or unpaired Student\'s t-test were used to determine significant differences between groups. The program used for statistical
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When a hour delay period was implemented for
2020-01-21
When a 6-hour delay Trehalose was implemented for the WRAM, neither of the E2-treated groups (E2-only and E2 + Levo) differed in WMC errors between the postdelay trials and the baseline trials. This suggests that exogenous E2 treatment protected from a delay-induced impairment in performance on work
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In this study the ASTM C and ASTM
2020-01-21
In this study, the ASTM C1260 and ASTM C1567 test methods were followed to conduct the ASR tests. Three mortar bars were prepared using three types of RHA (600-RHA, 150-RHA, and 44-RHA) and CFA. To prepare the mortar bars, the OPC was replaced by each type of RHA for 10% and 20%, respectively by wei
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Studies carried out with LTRAs before the identification of
2020-01-20
Studies carried out with LTRAs before the identification of the CysLT2R, showed a controversial picture, as results that suggest a role for cysteinyl-LTs in the expansion of ischemic damage and in cardiac dysfunction during reperfusion [5], [68], [69] were evenly balanced by others suggesting that t
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pkr Eukaryotic cell cycle machinery is thought to appropriat
2020-01-20
Eukaryotic cell cycle machinery is thought to appropriately modulate cell proliferation and cell expansion in various developmental stages and environmental conditions. The core feature of cell-cycle control is the fluctuation of CDK activity, which is regulated by three interactive and conserved me
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Stable carbon and nitrogen isotope
2020-01-20
Stable carbon and nitrogen isotope ratios in bone collagen and carbon isotope ratios in bone apatite data were obtained by the means of the techniques described in supplementary data (SD1). For collagen, standard indicators have been used to assess its preservation, such as collagen yield, carbon an
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It should be noted that not only glyphosate but
2020-01-20
It should be noted that not only glyphosate but E2 at the same concentration range (10−11-10−7 M) also showed similar effects on the expression of the atrial natriuretic peptide receptor regulating proteins. Furthermore, we could not see a significant difference among this concentration range of gl
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Oseltamivir Both the kK and kK mediated
2020-01-20
Both, the kK3 and kK5-mediated ubiquitination leads to rapid internalisation of target proteins followed by lysosomal degradation, similar to that seen for MARCH-1/8 [77]. Ubiquitination activity of kK3 and kK5 depends on the positioning of the targeted lysine (or cysteine) residues [22]. The positi
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In another study Nutlin a mediated p activation
2020-01-20
In another study, Nutlin-3a-mediated p53 activation induced strong negative impact on NF-κB signaling in LPS-stimulated neutrophils and macrophages [34]. Nutlin-3a limited cellular immune response to LPS, partly by attenuating DNA binding activity of NF-κB and impairing transcription of its target c
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Everolimus treatment showed an increase in
2020-01-20
Everolimus treatment showed an increase in the number of plaques and a reduction in plaque size, depending on concentration and treatment time (Fig. 1, Fig. 2). Everolimus-pretreated LJH685 sale adsorbed less virus with more plaque formation in the initial phase of infection (Fig. 3). The ability a
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To determine direct DDR binding partners and to
2020-01-20
To determine direct DDR1-binding partners and to further connect to Akt and mTOR signaling, we performed mass spectrometry on DDR1 immunoprecipitates and found various candidates of the Akt and mTOR pathway such as LARP1 (La-related protein 1) and RPS6 (40S ribosomal protein S6/ S6). Most intriguing
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Interestingly Carver Johnson and Kim
2020-01-20
Interestingly, Carver, Johnson, and Kim (2016) investigated a polymorphism in the OPRM1 μ-opioid receptor gene for its role in sensitivity to social contexts. The G allele of this polymorphism was associated with higher levels of sensitivity. The authors found significant interactions, e.g. the nega
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Another significant finding in our
2020-01-20
Another significant finding in our study was the demonstration that the axon-protective action associated with CK2 inhibition correlated with preservation of mitochondrial structure and function in DIDS receptor (Fig. 11). Because of the consistent protection conferred by CK2 inhibition during OGD,
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In conclusion we have identified Ednra
2020-01-20
In conclusion, we have identified Ednra as a downstream direct target of Hoxa9 and Meis1. Upregulation of Ednra has a role in the progression of Hoxa9+Meis1-induced leukemia and targeting Ednra together with other chemotherapies may have therapeutic benefits for leukemia [30]. Ednra inhibitors in th
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Since the number of peptides hydrolized by PEP
2020-01-19
Since the number of peptides hydrolized by PEP is quite large, it is not easy to relate the increase of enzymatic activity with the altered changes of a concrete peptide. However, it is noticeable that imbalances of several natural substrates of PEP [6], such as angiotensins, bradykinin, vasopressin
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