• Evans Blue tetrasodium salt Ramatroban a thromboxane A recep

  2020-07-31

  

  Ramatroban (), a thromboxane A2 receptor (TP) antagonist currently used for the treatment of allergic rhinitis, was shown to be a potent CRTH2 antagonist. Indomethacin (), a well-known analgesic and cyclooxygenase 1 and 2 (COX-1 and COX-2) enzyme inhibitor, was reported to show CRTH2 agonist potency

• br Materials and methods br

  2020-07-31

  

  Materials and methods Results Conclusion In summary, we have predicted three-dimensional structures of open and closed conformations of Theileria annulata enolase by using the method of homology modeling. Comparative and comprehensive structural analysis indicated that preserved structural

• br Materials and methods br Results br Discussion Imatinib

  2020-07-31

  

  Materials and methods Results Discussion Imatinib inhibits the tyrosine kinase activities of ABL, as well as the c-KIT and PDGF (platelet derived growth factor) Atorvastatin Calcium kinases, and is an effective therapy for chronic myeloid leukemia and c-KIT and PDGF receptor-dependent gast

• In an effort to discover

  2020-07-31

  

  In an effort to discover additional GPCRs directing the migratory events of responding B cells, we identified Epstein-Barr virus (EBV)-induced gene 2 (EBI2) as a promising candidate. The gene encoding EBI2 (Ebi2, also known as Gpr183) was originally identified together with Ebi1 (Ccr7) as the most h

• eht library Another important issue that requires clarificat

  2020-07-31

  

  Another important issue that requires clarification is the contribution of TLS regulators to replication of undamaged DNA. TLS pols are certainly required for the synthesis across difficult-to-replicate DNA structures such as common fragile sites [4], but their participation in undamaged DNA replica

• The residue selectivity of vCPH was investigated using

  2020-07-31

  

  The residue selectivity of vCPH was investigated using peptides based on PA-Hyp-KPAPK (PA-Hyp-K-X-APK with the X position being varied); the results revealed no evidence of reaction between vCPH and other proteinogenic amino acids, indicating that vCPH is highly selective for prolyl-residues (Supple

• br Materials and methods br

  2020-07-30

  

  Materials and methods Results and discussion Concluding remarks Conflicts of interest Acknowledgments The authors acknowledge the financial support of DGAPA, UNAM (PAPIIT grant IN220317), Consejo Nacional de Ciencia y Tecnología (CONACYT grants 252123 and 283524), and Faculty of Chemi

• While we previously demonstrated that TraG is inhibited by s

  2020-07-30

  

  While we previously demonstrated that TraG is inhibited by specific transglycosylase inhibitors and that enzymatic activity is strongly reduced upon mutation of the potential catalytic core (Arends et al., 2013), the enzymatic mechanism of both domains was not assigned. Here, by mass spectrometry an

• Three kinase inhibitors dasatinib type I

  2020-07-30

  

  Three kinase inhibitors dasatinib (type I), imatinib (type II) and nilotinib (type II), identified initially as inhibitors of tyrosine kinase BCR-ABL, were found to target DDRs in a chemical proteomic profiling study (Bantscheff et al., 2007, Hantschel et al., 2008). These tyrosine kinase inhibitors

• We also observed that the ability of DGK

  2020-07-30

  

  We also observed that the ability of DGKβ to induce the formation of filopodia (Fig. 1) is positively correlated with the extent of its plasma membrane localization and F-actin colocalization (Fig. 2, Fig. 3 and Table 1). The results suggest that DGKβ must be localized at the plasma membrane and col

• Overall our results indicate that the cutaneous HPV

  2020-07-30

  

  Overall, our results indicate that the cutaneous HPV8 E7 oncoprotein has a leucine rich NES (76IRTFQELLF84) within the zinc-binding domain that interacts with CRM1 export receptor and mediates its nuclear export. We have previously shown that the mucosal low risk HPV11 E7 has a leucine-rich NES (76I

• Together the results of the alkaline elution

  2020-07-30

  

  Together, the results of the alkaline elution and cell growth/cytotoxicity data strongly suggest that both the activity and DNA interstrand cross-linking produced by ZD2767P + CPG2 is due to bifunctionality of the active ZD2767D drug that is generated from ZD2767P. The monofunctional ZD2767D analogu

• It was found that qCPA all approaches significantly improves

  2020-07-30

  

  It was found that qCPA (all approaches) significantly improves the prediction of binary VLE and the correlation of LLE between CO2+n-alkane mixtures. A significantly smaller interaction parameter is needed to correlate the experimental data with qCPA compared to the CPA approaches. When it comes to

• HOSu receptor br Introduction Phase behavior models for mixt

  2020-07-30

  

  Introduction Phase behavior models for mixtures of bitumens (or heavy oils) and n-alkanes are required for the simulation of solvent-assisted in situ heavy oil recovery processes, solvent based oil sand extraction processes, and solvent deasphalting processes [1,2]. These mixtures can form multip

• Z-FA-FMK In terms of mode of action inhibition of cytochrome

  2020-07-30

  

  In terms of mode of action, inhibition of cytochrome P450 s by DEET could provide a viable explanation for the confusion hypothesis (Ramirez et al., 2012). Carr et al. (2017) identified putatively Haller’s organ-specific D. variabilis P450 transcripts, suggesting that they function as odorant degrad

15208 records 763/1014 page Previous Next First page 上5页 761762763764765 下5页 Last page