• br Materials and methods br Results br Discussion CDK

  2020-12-11

  

  Materials and methods Results Discussion CDK4 has been identified recently as a potential therapeutic target in human breast cancer, liposarcoma, melanoma, and glioblastoma [[37], [38], [39]]. Due to the importance of CDK4 activity in cancer cells, CDK4 inhibitors have emerged as promising

• As one of the two receptors for the

  2020-12-11

  

  As one of the two receptors for the primordial chemokine CXCL12, ACKR3 exists in jawless fish (Bajoghli, 2013, Nomiyama et al., 2011, Venkatesh et al., 2014). The sea lamprey genome contains two copies of the ACKR3 gene (Ensembl Acc. Nos.: ENSPMAP00000011187 and ENSPMAP00000011401) (Table 1), both e

• In humans individual differences in prefrontal dopamine are

  2020-12-11

  

  In humans, individual differences in prefrontal dopamine are partially caused by the Val158Met single-nucleotide polymorphism on the catechol-O-methyltransferase gene (COMT). This gene controls activity of the COMT enzyme, which degrades extracellular catecholamines including dopamine. The Val varia

• NPC L expression is both tissue and species

  2020-12-11

  

  NPC1L1 expression is both tissue- and species-specific. Consistent with its function, NPC1L1 is mainly localized to the brush border membrane of enterocytes and the canalicular membrane of hepatocytes. NPC1L1, which is expressed in the liver of humans and rats but not mice, mediates cholesterol PD 0

• Overall we found that all hormone treatment groups

  2020-12-11

  

  Overall, we found that all hormone treatment groups were able to learn spatial working and reference memory tasks, as shown by their performance across days on the WRAM (days 2–12, collapsed across the 4 trials) and the MWM (days 1–5, collapsed across the 4 trials). During the acquisition phase of t

• The authors then showed that Spt interacts

  2020-12-11

  

  The authors then showed that Spt6 interacts directly with the PRC2 subunit Suz12. This interaction occurs in solution but not on chromatin, suggesting that Spt6 may prevent PRC2 recruitment by binding to Suz12. They then mapped the domains in both Spt6 and Suz12 that are involved in this interaction

• Being a rare renal tumor

  2020-12-11

  

  Being a rare renal tumor, its description as primary renal tumor has been confined to the documentation of anecdotal case reports in the past [4], [9], [10], [11]. However, recent years have seen an increased interest in defining ES/PNET of kidney as a distinct entity, with the study undertaken by t

• The work described by Dong Groves and co workers tested

  2020-12-11

  

  The work described by Dong, Groves, and co-workers (11) tested the hypothesis that neural stem cell development is sensitive to the clustering and mechanical state of the EphB4:ephrin-B2 receptor-ligand complex. They show that the quality of ephrin-B2-ligand signaling depends on its biophysical stat

• EC barrier dysfunction triggered by inflammatory mediators i

  2020-12-11

  

  EC barrier dysfunction triggered by inflammatory mediators involves more than one mechanism, explaining the partial attenuation of EC barrier compromise obtained with PKA and Epac activators. PKA-dependent phosphorylation of vasodilator-stimulated phosphoprotein (VASP) has been shown to make a posit

• br Results and discussion br Conclusion Recent studies showe

  2020-12-11

  

  Results and discussion Conclusion Recent studies showed that EGFR signaling is involved in inflammatory response in several inflammatory conditions. The normal inflammatory macrophage KL 001 show EGFR-dependent production of inflammatory mediators. Nevertheless, the development of EGFR inhibi

• br Experimental Procedures Further details and an outline of

  2020-12-10

  

  Experimental Procedures Further details and an outline of resources used in this work can be found in Supplemental Experimental Procedures. Introduction In response to T cell-dependent (TD) antigen stimulation, antigen-specific GSK503 migrate to the periphery of B cell follicles and interfoll

• br Acknowledgments This work was supported

  2020-12-10

  

  Acknowledgments This work was supported by Grants from the National Research Foundation (2010-0000782) and the National Center for GM Crops (PJ008152) of the Next Generation BioGreen 21 Program funded by the Rural Development Administration, Republic of Korea, to W.T.K. Introduction Ubiquityl

• br Development of the double strand break repair model for

  2020-12-10

  

  Development of the double strand break repair model for meiotic recombination Meiotic recombination was first described by Frans Alfons Janssens using TAME in the salamander Batracoseps attenuatus in 1909 [21] and then further elaborated at the genetic level in Drosophila by Thomas H. Morgan [22

• BB94 br Materials and methods br Statistical analysis All

  2020-12-10

  

  Materials and methods Statistical analysis All statistical analyses were performed using SPSS software version 20. Protein BB94 data of DNMTs and clinicopathological parameters were collected. Mann-Whitney U Test was used to assess the differential expression of nonparametric data of DNMTs pr

• As the first allotetraploid fish in the world our

  2020-12-10

  

  As the first allotetraploid fish in the world, our lab selectively breed the allotetraploid hybrid fish (4nAT, 4n = 200) from the distant hybridization offspring F3 of female Red Crucian Carp (Carassius auratus red var., abbreviated as RCC, 2n = 100) and male Common Carp (Cyprinius carpio L., abbrev

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