• br Introduction Chronic rhinosinusitis with

  2022-06-20

  

  Introduction Chronic rhinosinusitis with nasal polyps (CRSwNP), a subgroup of chronic rhinosinusitis (CRS), is a chronic inflammatory condition of the nasal and paranasal sinuses. CRSwNP is characterized by grape-like structures with dense inflammatory infiltrates, loose fibrous prostaglandin end

• Lactate as administered in these models is

  2022-06-20

  

  Lactate as administered in these models is metabolized rapidly and it appears that transient engagement of GPR81 with lactate serum concentrations in the range of moderate exercise physiology, as measured here at 3–4 mmol/L, are sufficient to suppress tissue macrophage NF-κB activation in our models

• br Acknowledgments br Introduction Myelin one of the

  2022-06-20

  

  Acknowledgments Introduction Myelin, one of the fundamental adaptations of vertebrates, is a multilamellar structure deriving from the spiral wrapping around the kv1.3 inhibitor of the plasma membrane of myelin forming glia, oligodendrocytes in the central nervous system and Schwann cells (SC

• br Conflict of interest statement br Acknowledgements

  2022-06-20

  

  Conflict of interest statement Acknowledgements We acknowledge the support of Zoetis Animal Health, Estrotect, Select Sires and Texas A&M AgriLife Research. The assistance of Randle Franke and Ernest Soto is also gratefully acknowledged. Background Luteal phase deficiency (LPD) is caused b

• The soluble receptor for advanced glycation

  2022-06-20

  

  The soluble receptor for advanced glycation end products has been already studied in physiological and pathological pregnancy. In accordance to our previous studies we showed increased sRAGE serum levels in women with threatening premature labor [15] and we described a negative correlation of sRAGE

• We confirmed a decrease in extracellular glutamate uptake an

  2022-06-20

  

  We confirmed a decrease in extracellular glutamate uptake and the presence of efflux in an endothelial cell model of oxygen-glucose deprivation (OGD), which effectively simulates the inefficient energy supply after brain injury [15], and analysed the function of endothelial EAATs and explored the ro

• br Materials and methods br Results br Discussion Our

  2022-06-20

  

  Materials and methods Results Discussion Our liver-specific Gck (−/−) mice and another line of liver-specific mice [13] exhibited impaired glucose tolerance. Furthermore, both knockout mice showed decreased hepatic glycogen content and reduced Pklr and Fas gene Dasatinib Monohydrate in the

• The genes for the receptors for

  2022-06-20

  

  The genes for the receptors for peptides similar to glucagon are dispersed on three human chromosomes, with two on chromosome 17 (GCGR and GLP2R) and one each on chromosomes 6 (GLP1R) and 19 (GIPR) (see Table S1). The exon–intron gene structures of these genes are similar, as are the genes for other

• As ghrelin effects are suspected to be mediated

  2022-06-18

  

  As ghrelin effects are suspected to be mediated by a heterogeneous population of G-protein-coupled-receptors [2], [21], other so far unknown subtypes of ghrelin receptors differing from the classical GHSR-1a may additionally exist that might also mediate ghrelin effects on the heart. Thus, the real

• Cx mimetic peptides short synthetic peptides corresponding t

  2022-06-18

  

  Cx mimetic peptides, short synthetic peptides corresponding to intracellular amino Nile Red sequences of diverse Cx have better specificity compared to traditional GJ blockers and openers. In particular, it was reported that Cx mimetic peptides reversibly inhibited GJ channel function in a concentr

• UNC0638 receptor Due to the presence of all

  2022-06-18

  

  Due to the presence of all FGFRs in the epithelium, there are several FGFs ligands that could be binding to these FGF receptors, namely FGFs 1–4, 8–10, 16 and 18–20. By evaluating the known roles of FGFs in epithelial-mesenchymal interactions and in bone development, this list can be reduced. For ex

• In conclusion a novel series

  2022-06-18

  

  In conclusion, a novel series of GPR40 agonists containing nitrogen heterocyclic rings derived from TAK-875 were designed and synthesized. The structural activity relationship studies indicated that the substituents on the nitrogen lumiracoxib had a remarkable effect on the GPR40 agonistic activity

• This profound cell type specificity of G a GLP

  2022-06-18

  

  This profound cell-type specificity of G9a/GLP complex modulation of neuronal plasticity is accentuated by studies employing genetic ablation of G9a in dopamine 1 receptor (Drd1)- and dopamine 2 receptor (Drd2)-expressing medium spiny neurons (MSNs) in the nucleus accumbens (NAc). Conditional G9a kn

• br Statistical analysis The mean standard

  2022-06-18

  

  Statistical analysis The mean, standard deviation, median, range, frequency, and percentage were used for data description. The chi-square (x2) test was used for analyses the differences in categorical variables in the 2-way table. Overall survival (OS) was defined as the time interval between t

• Given the major differences between the

  2022-06-18

  

  Given the major differences between the molecular regulation of the genes encoding HO-1 (HMOX1) in mice and humans, it is not appropriate to utilize mouse models for mechanistic analyses of human HMOX1[35]. In addition, it has been reported that drugs, such as statins, as well as stressors and the r

16051 records 442/1071 page Previous Next First page 上5页 441442443444445 下5页 Last page