• Compound containing dimethylglutarimide P cap P propyl group

  2022-08-03

  

  Compound containing, dimethylglutarimide P-cap, P propyl group, α-methylbenzyl urea resulted in inhibitor with much improved binding (=0.064μM) and EC=0.3μM. This was an aza-peptide analog with an EC comparable to our first generation clinical candidate . Analog was evaluated for its selectivity

• br Soluble guanylyl cyclase nitric oxide and

  2022-08-03

  

  Soluble guanylyl cyclase, nitric oxide and nitric oxide synthase The primary and best-studied endogenous activator of soluble guanylyl cyclase (sGC) is nitric oxide (NO), which was originally describe as endothelium-derived relaxing factor for its potent ability to relax blood vessels in response

• Ginkgolic Acid C15:1 Several studies have found that GPR pos

  2022-08-02

  

  Several studies have found that GPR55 possesses a distinct pharmacology from that of CB1 and CB2, and that only certain cannabinoids act at this receptor. In transfected Ginkgolic Acid C15:1 expressing hGPR55, out of more than 20 synthetic and endogenous cannabinoids evaluated, only 2 compounds, SR

• So far GnRH receptors have been detected in the

  2022-08-02

  

  So far, GnRH receptors have been detected in the human ovary, but their physiological importance is still unclear (). In particular, GnRH receptors as well as GnRH types I and II have been localized in the granulosa Edrophonium chloride australia of pre-ovulatory follicles, but not of follicles fro

• br Experimental br Acknowledgment This work was supported in

  2022-08-02

  

  Experimental Acknowledgment This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan. Glyoxalase I (GLO1) is a zinc enzyme that catalyzes the isomerization of a hemithioacetal, formed from glut

• br Brief overview of the glutamate system and rationale for

  2022-08-02

  

  Brief overview of the glutamate system and rationale for targeting the glycine site of NMDARs In the central nervous system (CNS), glutamate is the major excitatory neurotransmitter and works in concert with gamma-aminobutyric praziquantel biltricide australia (GABA), the primary inhibitory neur

• After brain injury adenosine levels rapidly

  2022-08-02

  

  After brain injury, adenosine levels rapidly increase in the brain [9,10]. As shown in our previous studies, the increased adenosine concentration acts on adenosine A2A receptors (A2ARs), increasing post-traumatic glutamate levels in the brain and exacerbating the severity of injuries [11,12]. Accor

• Activation of Akt signaling is common in nearly all

  2022-08-02

  

  Activation of Akt signaling is common in nearly all of the human malignancies (Altomare & Testa, 2005). It has been reported that microRNA-200c targets Akt signaling pathway to inhibit cell apoptosis of pituitary adenoma (Liao et al., 2014). In addition, Akt signaling pathway regulates the expressio

• br Methods br Results br Discussion Among three

  2022-08-02

  

  Methods Results Discussion Among three main signaling pathways activated by bFGF, the MAPK pathway was found to be involved in the upregulation of GR levels. So far, there have been a few candidates that could connect activated ERK to the upregulation of GR. One likely candidate is the zinc

• Olanzapine has been reported to attenuate insulin secretion

  2022-08-02

  

  Olanzapine has been reported to attenuate insulin secretion, cause insulin resistance (Chintoh et al., 2008) and reduce whole body carbohydrate oxidation (Klingerman et al., 2014). However, a blunting of these effects in Gcgr−/− mice would not appear to explain the protection against olanzapine-indu

• eukaryotic initiation factor Recently several dual GLP GIP r

  2022-08-02

  

  Recently, several dual GLP-1/GIP receptor agonists have been developed as a treatment of type II diabetes. These peptides can activate both the GLP-1 and the GIP receptor. Such dual receptor agonists are superior compared to single GLP-1 analogues such as liraglutide (Finan et al., 2013). Previously

• Cx mimetic peptides short synthetic peptides corresponding t

  2022-08-02

  

  Cx mimetic peptides, short synthetic peptides corresponding to intracellular amino 33187 sequences of diverse Cx have better specificity compared to traditional GJ blockers and openers. In particular, it was reported that Cx mimetic peptides reversibly inhibited GJ channel function in a concentrati

• br Conflicts of interests br Acknowledgements

  2022-08-02

  

  Conflicts of interests Acknowledgements We thank Drs. T. Tomita and T. Iwatsubo (Tokyo University, Tokyo, Japan) for anti-presenilin 1-CTF antiserum, Dr. A. Takashima (Gakushuin University, Tokyo, Japan) for anti-Pen-2 antiserum and the laboratory members for helpful comments and discussion. M

• Phloretin receptor Piroxicam belongs to the oxicam family

  2022-08-02

  

  Piroxicam belongs to the oxicam family of NSAIDs and a special attention has been drawn to this drug because of its multifunctional potential [5], [27], [28]. Chemically, piroxicam (4-hydroxy-2-methyl-N-2-pyrimidyl-2H-1,2-benzothiazine-3-carboxyamide) is an enolic Phloretin receptor with a size comp

• Although our knowledge of how FAs affect GLP producing

  2022-08-02

  

  Although our knowledge of how FAs affect GLP-1-producing L-cells is sparse and incomplete, increased intracellular ceramide [6], ER stress [12], and increased production of ROS [9] are indicated mediators of the lipotoxicity induced by SFA (16:0). However, the role for/interaction between these medi

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