• To overcome these resistance mechanisms in APL

  2019-06-12

  

  To overcome these resistance mechanisms in APL cells, a number of drugs have been tested. Tamibarotene is approximately 10 times more potent than ATRA as an in vitro inducer of differentiation, and is chemically more stable than ATRA [5]. Although the precise mechanism of the combination of tamibaro

• Acute kidney injury is a

  2019-06-12

  

  Acute kidney injury is a common disorder worldwide, occurring in more than 13 million people every year, 85% of whom live in low-income or middle-income countries (LMICs). The disease imposes a severe burden of morbidity and mortality, with a major economic effect on health-care expenditure worldwid

• Results from the present study also showed

  2019-06-12

  

  Results from the present study also showed improvement in timelines for measles immunisation, which is scheduled at 9 months of age, almost a gap of 6 months from the last vaccine according to EPI schedule for LMICs. Although the major focus up until now has been on reminder messages, the impact of

• br Methods The study population

  2019-06-12

  

  Methods The study population comprised 150 patients who underwent implantations of Medtronic dual chamber pacemakers and who had maintained both atrial and ventricular sensing (either in DDD, DDI, or VDD modes) from March 2008 to October 2010. The implanted fxr agonist generators were either Kap

• Several mechanisms for cardiac involvement have

  2019-06-12

  

  Several mechanisms for cardiac involvement have been propounded as (1) direct cardiac involvement, (2) hematogenous spread, (3) lymphatic spread, (4) spreading from the venous system, such as the pulmonary vein or inferior vena cava. In cases of pericardium metastasis, most spreading routes result f

• No conviene ignorar la enorme influencia

  2019-06-12

  

  No conviene ignorar la enorme influencia cultural de Estados Unidos en la formación intelectual de Vasconcelos, so pena de caer en contradicciones. Ulises criollo se asienta en una tradición muy estadounidense, la de una fascinación por las cuestiones de la individualidad, la identidad y la autobiog

• br Eva Leticia Ordu a Trujillo investigadora del en uno

  2019-06-12

  

  Eva Leticia Orduña Trujillo, investigadora del en uno de sus más recientes libros , aborda un tema fundamental para explorar, debatir y profundizar sobre nuestras aún muy débiles democracias latinoamericanas, Biotin-HPDP través de la actuación de nuestros estados en sedes judiciales internacionale

• Patients with endophytic tumors had a fold

  2019-06-11

  

  Patients with endophytic tumors had a 2.6-fold higher rate of local recurrence than those with exophytic tumors. The 5-year local control rates were 64% and 95% in those with endophytic and exophytic lesions, respectively. The correlation of tumor morphology with local recurrence in patients with ea

• salubrinal Cost effectiveness is another major concern for t

  2019-06-11

  

  Cost effectiveness is another major concern for the governments in countries with public health system. Van-den Hout WB et al. at Netherlands [7] did a cost utility analysis showing the cost of radiation treatment including re-treatment for bone metastases using SF versus MF were €2438 versus €3311

• We are aware that physician

  2019-06-11

  

  We are aware that physician surveys have been previously used to assess; bisphosphonate use for bone pain [14], bisphosphonate use in metastatic breast cancer patients [15] and radiotherapy use for painful bone metastases [16] but are not aware of physician surveys being used to help design trials o

• Editorial opinion piece Many patients with advanced cancer

  2019-06-11

  

  Editorial/opinion piece Many patients with advanced cancer will develop bone metastases and associated complications, including severe pain and debilitating skeletal-related events (SREs), which require radiotherapy, surgery or changes to antineoplastic regimens [1–3]. Fortunately, there are effect

• ICG which simply and non invasively measures changes in thor

  2019-06-11

  

  ICG, which simply and non-invasively measures changes in thoracic impedance generated by fluctuating blood volumes during the cardiac cycle, allows for the calculation of stroke volume, CO, and other derived parameters[17]. In recent years, the accuracy of ICG has been greatly improved by the advent

• G nesis y antecedentes Juan Mar a Guti rrez

  2019-06-11

  

  Génesis y antecedentes Juan María Gutiérrez nace en Buenos Aires, meses previos gabab la Revolución de Mayo de 1810, donde las efemérides continentales marcan el inicio de la independencia del Río de la Plata y de casi todas las regiones dominadas por el imperio español. Es, por tanto, hijo del mov

• In addition we are continuing our regular editorial

  2019-06-11

  

  In addition, we are continuing our regular editorial policies of commissioning more specialised Clinical Reviews and Series across Group to provide a more focused and in-depth assessment for key diseases. And beyond providing knowledge and information, we want to encourage academic and practising c

• Ad Mapu lleg a convertirse en un gran

  2019-06-11

  

  Ad Mapu llegó transcription factor convertirse en un gran referente que contribuyó al fortalecimiento de la conciencia de la situación mapuche, así lo explica Víctor Toledo al mencionar que es en este momento cuando aparece bosquejada la autodeterminación como propuesta del pueblo mapuche, y recuerd

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